Myocardial Perfusion Utilization and Case Studies

PET/CT imaging provides a way to assess the severity of heart disease and measure its impact on heart function. Clinical studies show an important role for PET/CT in screening for coronary heart disease, assessing flow rates and flow reserves, and distinguishing viable from nonviable heart tissue. Advancements in quantification software give the clinician the ability to easily calculate blood flow values at peak stress and rest as well as obtain the coronary flow reserve estimate. Studies have evaluated the impact of estimating flow values and flow reserve in combination for assessing coronary artery disease and identifying triple vessel ischemia.1

Myocardial perfusion imaging indications

  1. Identifying ischemic disease, or reduced blood supply to the heart
  2. Detecting coronary artery disease even before clinical symptoms show
  3. Determining the extent of coronary artery disease before and after treatment
  4. Demonstrating whether a surgery to reverse the effects of a blockage will improve the function of the heart

Title Description Author
Case 01 Normal during both exercise and rest University of Tennessee Medical Center, Knoxville, TN, USA
Case 02 Normal during rest but is reduced in part of the heart during exercise University of Tennessee Medical Center, Knoxville, TN, USA
Case 03 Reduced in a part of the heart during both exercise and rest PET Medical Imaging Center, Grand Rapids, MI, USA

References:
  1. Parkash et al. Potential Utility of Rubidium 82 PET Quantification in Patients with 3-Vessel Coronary Artery Disease. J Nucl Cardiol 2004; 11:440-49