Metastatic Bone Disease Case Study 02


Clinical History
42-year-old female patient with breast carcinoma was referred for evaluation of possible skeletal metastases by sodium fluoride F 18 (18F NaF) bone PET/CT imaging.

Imaging Findings
NUCLEAR MEDICINE 18F NaF BONE PET/CT SCAN
STATED REASON FOR REQUEST: Staging breast cancer
RADIOPHARMACEUTICAL ADMINISTERED: 18F NaF
TECHNIQUE: A whole-body PET/CT study was performed approximately one hour after intravenous administration of 18F NaF.

Normal distribution of the tracer was visualized throughout the entire skeletal system, except for mild degenerative changes in the lower lumbar vertebrae (arrows). There was no evidence of skeletal metastatic disease.

Discussion
The 18F NaF bone PET study is more sensitive than bone scanning using gamma camera systems for detecting osseous lesions for several cancers like breast and prostate.1 It can be used as an alternative to bone scanning. The improved image quality, cross sectional visualization and CT correlation available with the PET/CT bone study further enhance diagnostic confidence for characterization of skeletal lesions, especially differentiation of benign from malignant.

Data courtesy of University of Tennessee Medical Center, Knoxville, Tennessee, USA

Reference:

1. Schirrmeister H. et al. Sensitivity in Detecting Osseous Lesions Depends on Anatomic Localization: Planar Bone scintigraphy versus 18F PET. J Nucl Med 1999; 40:1623-1629.

* Any of the protocols presented herein are for informational purposes and are not meant to substitute for clinician judgment in how best to use any medical devices. It is the clinician that makes all diagnostic determinations based upon education, learning and experience.