Metastatic Bone Disease

Metastatic tumors develop when cancer cells break off from a primary tumor and enter the bloodstream. These cells can reach nearly all tissues in the body, and bones are a common place for these cancer cells to settle and start growing. More than 90% of all these metastatic lesions in bone are caused by a small number of primary tumors, including breast, lung, kidney, prostate, and thyroid.

It is extremely important in the diagnosis and staging of these cancers to determine the true extent of the disease and whether the tumor has spread to the skeleton. The patient�s prognosis, or the outlook for recovery, depends upon determining the stage of the cancer and the best treatment options. For early cancer, surgery may be all that is needed, and so it is critical to exclude the presence of any bone metastases before the potentially curative surgery is performed. For cancer that is more advanced, chemical or radiation therapy may be needed as well to increase the chance of a cure or delay the cancer's progression. After treatment is complete, it is important to know if any active cancer cells remain in the body. This is called restaging.

A whole-body sodium fluoride F 18 (18F NaF) bone PET/CT scan can be performed before treatment to help the physician determine the most appropriate treatment, and after treatment to help determine the effectiveness of the treatment, to image the tumor�s response to therapy and to detect recurrence in treated lesions.

View and print: 18F NaF Bone PET and PET•CT Imaging Patient Instructions

PET/CT Utilization and Case Studies

PET/CT is a noninvasive test that physicians utilize to stage the entire body for the presence or absence of active tumor, localize the tumor, assess the tumor response to treatment and detect recurrence in treated lesions.

Important Safety Information
For Intravenous Use


Sodium Fluoride F 18 Injection is a radioactive diagnostic agent for positron emission tomography (PET) indicated for imaging of bone to define areas of altered osteogenic activity.

Allergic Reactions:
As with any injectable drug product, allergic reactions and anaphylaxis may occur. Emergency resuscitation equipment and personnel should be immediately available.
Cancer Risk: Sodium Fluoride F 18 Injection may increase the risk of cancer. Use the smallest dose necessary for imaging and ensure safe handling to protect the patient and health care worker.

No adverse reactions have been reported for Sodium Fluoride F 18 Injection based on a review of the published literature, publicly available reference sources, and adverse drug reaction reporting system.

Full prescribing information for Sodium Fluoride F 18 Injection


PETNET Solutions, 810 Innovation Drive, Knoxville, Tennessee, USA